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The tetracycline compounds of the invention include, for example, compounds wherein X is CR 6R 6'; R 4 and R 4' are hydrogen or the oxygen of a carbonyl group; R 2, R 2', R 6, R 6', R 8, R 10, R 11, and R 12 are each hydrogen; R 4' and R 4" are lower alkyl; and R 5 is hydroxy or hydrogen. Pijn is een bijwerking die wel eens voorkomt bij de afbouw van cortisone maar weinig mensen hebben die pijn.